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pentobarbital will lessen the level or influence of tipranavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers improve fee of toremifene metabolism, reducing the steady-state foc